Histological Typing of Urinary Bladder Tumours

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Authors: Mostofi , F. The WHO classification of bladder tumours anticipated a probable need for eventual revision of the criteria for diagnosing papillary and flat bladder neoplasia. A workshop sponsored by the WHO consisting of pathologists, urologists, cytologists, oncologists and basic scientists interested in bladder tumours addressed this subject, and after a follow- -up meeting sponsored by the International Society of Urological Pathology, the classification and terminology used in this text were agreed upon.


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A major change is in the introduction of a new category: papillary urothelial neoplasm of low malignant potential. Many of the tumours previously designated as papillary transitional cell carcinoma, grade I now fall into that category. Another major change is in the designation of flat lesions, and this includes a definition of carcinoma in situ.

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Furthermore, a number of variant forms of urothelials carcinomas are included as well as new entities not recognized when the 1st edition was issued. Although the emphasis of this classification is on histological typing, in the examination of kidney tumours, consideration should be given to the degree of cellular anaplasia, the extent of local spread, vascular and lymphatic invasion, and the occur- rence of metastasis.

The scheme of histological grading suggested here is as fol- lows: Grade I applies to the tumours that have the least degree of cellular anaplasia compatible with a diagnosis of malignancy;. This scheme is applicable to the carcinomas of the renal parenchyma and pelvis. Passar bra ihop.

Histological Typing of Urinary Bladder Tumours

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